Pathophysiology/Clinical Variability of Sickle Cell Disease

Sickle cell disease (SCD), though caused primarily by a single mutation, has protean manifestations. The research program at the Sickle Cell Unit has been varied over the years. In an attempt to improve focus to pursue excellence, priority has been given to specific areas in which we have a track record and particular strengths. Some have been covered under other themes, in particular psychosocial aspects and implementation research. Areas examined in this programme are primarily clinical trials, painful crisis and chronic organ injury in SCD


  • Neuropathic Pain in Jamaicans with Sickle Cell Disease
  • A prospective open label, pharmacokinetic study of an oral Hydroxyurea solution in children with sickle cell anemia